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Core Technology
Panlabs is dedicated to utilizing its expertise to offer customized services that help global enterprises enhance the value of microbial applications and optimize industrial production efficiency.
Strain Improvement
With over 50 years of experience in industrial microorganism and enzyme engineering, Panlabs possesses comprehensive capabilities in both aerobic and anaerobic systems. Through customized strain improvement and media optimization, we enhance productivity and process stability. Combined with high-throughput screening platforms and automated systems, we accelerate strain optimization and deliver efficient development solutions.
Global Microbial Strain Library
Panlabs maintains a collection of over 20,000 fungal and actinomycete strains, supporting natural product discovery and bioactivity exploration with broad applications in pharmaceuticals, agriculture, and biotechnology. Our strain library is not subject to the Nagoya Protocol, enabling global collaboration and product development.
Microbial Strain Licensing
Panlabs offers selected proprietary strains capable of producing a variety of key natural compounds, with applications in drug development, immunology research, pet health, agriculture, and the biotechnology industry.
The associated strains and production processes are available for licensing and technical collaboration. Supporting research data and fermentation process information can also be provided upon request.
| No. | Product | Strain | Properties / Mechanism | Application |
| 1 | Doxorubicin | Streptomyces sp. | Intercalates into DNA and inhibits topoisomerase II, inducing apoptosis. |
Oncology therapeutics, Source of ADC cytotoxic payloads. |
| 2 | Staurosporine/Midostaurin | Streptomyces sp. | Protein kinase inhibition, disrupting cellular signaling pathways. |
Drug discovery, Signal transduction research |
| 3 | Calicheamicin | Micromonospora sp. | Binds to DNA and induces double- strand breaks. |
ADC cytotoxic payload, DNA damage research |
| 4 | Tacrolimus | Streptomyces sp. | Calcineurin inhibition, blocking T-cell activation. |
Immunosuppression, Transplantation and immunology research. |
| 5 | Milbemycin | Streptomyces sp. | Modulates chloride ion channels, leading to parasite paralysis. |
Veterinary pharmaceuticals, Agricultural applications. |
| 6 | Spinosad | Saccharopolyspora sp. | Acts on the insect nervous system, Causing paralysis. |
Insecticides, Veterinary parasite control. |
| 7 | Paraherquamide | Penicillium sp. | Neuromuscular blocking activity. |
Antiparasitic drug development, Neuroscience research |
| 8 | Penicillin G & Penicillin V | Penicillium sp. | Inhibits bacterial cell wall synthesis. |
Antibiotic therapy. |
| 9 | Coenzyme Q10 (CoQ10) | Rhodobacter sp. | Participates in electron transport and exhibits antioxidant activity. |
Dietary supplements, Food and Cosmetic applications |
Service Options Provided
Panlabs focuses on solving common technical challenges in the fermentation and manufacturing processes. Through innovative technologies and professional services, we enhance production efficiency and optimize processes, including:
Increase strain productivity and yield
Reduction of by-product formation
Enhance strain stability
Lower fermentation solution viscosity
Improved media adaptability and utilization efficiency
Shorten production time
Example 1
COMBINATION OF STRAIN IMPROVEMENT AND MEDIA DEVELOPMENT
(Terpenoid/Polyketide Derivative, Fungi)
Example 2
RATIONAL SELECTION OF RIBOSOME ENGINEERING
(Cyclic Polypeptide, G(-) Bacteria)
Hit rate:
Antibiotic resistance selection (ribosome engineering): 43% (3/7)
Random selection: 5.8% (4/69)
Example 3
YIELD IMPROVEMENT OF A FUNGAL ENZYME
Example 4
STRAIN IMPROVEMENT BY COMBINING GENETIC ENGINEERING AND CLASSICAL MUTATION
Combing heterologous gene expression with molecular and classical yield improvement, we optimized lactoferrin production.
For our client Agennix, Inc. (Houston, TX, USA) (Bio/Technology, 1995,13:498-503)
