Strain & enzyme Improvement

problems we solve
Provide customized services with our expertise to help companies around the world solve their microbial and enzymatic productivity problems.

Panlabs has more than 45 years of industrial microbial strain development experience, and is familiar with a variety of aerobic and anaerobic microbial operations. We help companies to improve microorganisms (various production strains or recombinant strains) by random mutation method with the combination of media optimization to enhance microbial productivity.

In addition to the existing large number of shake flask fermentation equipment, Panlabs has introduced automated and miniaturized fermentation equipment to speed up the screening efficiency to provide the excellent strains required by our customers.

In terms of enzyme improvement, Panlabs uses molecular technology and protein engineering such as site-directed mutation or directed evolution to improve enzymes for client's needs in the development of green catalytic processes.

OPTIONS WE PROVIDE
Panlabs can provide and assist companies in solving the microbial production problems they often encounter:
Increasing the productivity
Reducing the proportion of impurities
Improving the stability of strains
Reducing the viscosity of fermentation broth
Improving the adaptability and utilization of culture media
Shorten production cycle time
Example 1
COMBINATION OF STRAIN IMPROVEMENT AND MEDIA DEVELOPMENT

(Terpenoid/Polyketide Derivative, Fungi)

Example 1
Example 2
RATIONAL SELECTION OF RIBOSOME ENGINEERING

(Cyclic Polypeptide, G(-) Bacteria)

Example 2

Hit rate:
Antibiotic resistance selection (ribosome engineering): 43% (3/7)
Random selection: 5.8% (4/69)

Example 3
YIELD IMPROVEMENT OF A FUNGAL ENZYME
Example 3
Example 4
STRAIN IMPROVEMENT BY COMBINING GENETIC ENGINEERING AND CLASSICAL MUTATION
Example 4

Combing heterologous gene expression with molecular and classical yield improvement, we optimized lactoferrin production.
For our client Agennix, Inc. (Houston, TX, USA) (Bio/Technology, 1995,13:498-503)

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