Panlabs Biologics Inc.
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Microbial Strains & Enzymes

Core Technology
Panlabs is dedicated to utilizing its expertise to offer customized services that help global enterprises enhance the value of microbial applications and optimize industrial production efficiency.


Strain Improvement

With over 50 years of experience in industrial microbial strain and enzyme improvement, Panlabs is highly skilled in operating various aerobic and anaerobic microorganisms. By employing professional, customized techniques combined with media optimization, we significantly increase the industrial production value of strains.In addition to large-scale shaker fermentation selection equipment, Panlabs has integrated micro-fermentation equipment and automated systems to accelerate strain screening, improve throughput and screening efficiency, and provide our customers with the highest quality strain solutions.


Enzyme Improvement and Products

Panlabs applies molecular biotechnology and protein engineering to develop highly efficient enzymes with enhanced catalytic performance. These enzymes operate under mild reaction conditions, reducing energy consumption and waste generationideal for green manufacturing and aligned with our customers' sustainability goals. Panlabs offers a diverse portfolio of enzymes for industrial and bioprocessing applications, including:

  • Enzymes: Amylase, Lipase, Nitrilase, Endonuclease, Glucose Oxidase
  • Proteases: SUMO protease, TEV protease

Global Microbial Strain Library

Panlabs is a leading microbial development company with a comprehensive strain library of over 20,000 fungal and actinomycete strains sourced from diverse geographical and ecological environments worldwide. We provide high-value natural products and microbial-based solutions with broad applications in pharmaceuticals, agriculture, functional foods, cosmetics, and environmental sustainability. Our strain library is not subject to the Nagoya Protocol, allowing unrestricted access for the discovery of novel bioactive natural compounds. If you are interested in exploring our microbial strain resources, please feel free to contact us!


Microbial Strain Licensing

We have curated a portfolio of representative microbial strains capable of producing key natural compounds, with applications in drug development, immunology research, veterinary and pet health, agricultural biocontrol, and biotechnology.
These strains and their production processes are available for licensing and technical collaboration, supported by comprehensive research data and detailed fermentation protocols. We sincerely invite interested partners to collaborate with us in advancing innovative applications and driving industrial development.

No. Product Strain Properties / Mechanism Application
1 Doxorubicin Streptomyces sp.
  • An anthracycline antitumor antibiotic that intercalates into double-stranded DNA and inhibits topoisomerase II, leading to disruption of DNA replication and induction of apoptosis.
  • Widely applied in the research and development of anticancer therapeutics.
  • It is a first-line chemotherapeutic agent for various cancers, especially breast cancer, lymphoma, and sarcoma.
  • A potential cytotoxic payload source for antibody–drug conjugates (ADCs).
2 Staurosporine/Midostaurin Streptomyces sp.
  • A natural broad-spectrum protein kinase inhibitor that induces apoptosis.
  • Acts on multiple cellular signaling pathways with significant impact on cell growth and differentiation.
  • Commonly used as a tool compound in pharmacological research.
  • An important lead compound for the development of protein kinase inhibitors.
3 Calicheamicin Micromonospora sp.
  • A potent enediyne-class antitumor antibiotic.
  • Binds to the minor groove of DNA and induces double-strand breaks, resulting in strong cytotoxicity.
  • Widely applied as a cytotoxic payload in antibody–drug conjugates (ADCs).
  • Serves as an important model compound for studying DNA damage and repair.
4 Tacrolimus Streptomyces sp.
  • A macrolide immunosuppressant that binds to FKBP12 and inhibits calcineurin, thereby blocking T-cell activation and IL-2 production.
  • Widely used in immunosuppression research, including transplantation immunity and autoimmune disease models.
  • Extensively applied in dermatology and studies of immune-related disease mechanisms.
5 Milbemycin Streptomyces sp.
  • A macrolide compound that binds to glutamate-gated chloride channels in the nerve and muscle cells of invertebrates, leading to paralysis and death of parasites.
  • Applied in animal health and parasitology research, particularly in studies of antiparasitic resistance and treatment.
  • Serves as a lead compound for the development of novel anthelmintics and agricultural pest control agents.
6 Spinosad Saccharopolyspora sp.
  • A natural macrolide insecticide that acts on nicotinic acetylcholine receptors in the insect nervous system, causing neuronal hyperexcitation and paralysis.
  • Relatively low in toxicity to mammals and characterized by environmentally friendly properties.
  • Widely applied in pest control and in insecticidal formulations for pets.
  • Characterized by its eco-friendliness, high selectivity, and strong safety profile.
7 Paraherquamide Penicillium sp.
  • An indole alkaloid compound that functions as a neuromuscular junction blocker, affecting the motor activity of parasites.
  • Has potential for development as a novel anthelmintic in the field of animal health.
  • Can be used as a tool compound for research on neuromuscular function.
Service Options Provided
Panlabs focuses on solving common technical challenges in the fermentation and manufacturing processes. Through innovative technologies and professional services, we enhance production efficiency and optimize processes, including:
Increase strain productivity and yield
Reduce by-product ratio
Enhance strain stability
Lower fermentation solution viscosity
Improve culture medium utilization and reduce costs
Shorten production time

Example 1
COMBINATION OF STRAIN IMPROVEMENT AND MEDIA DEVELOPMENT

(Terpenoid/Polyketide Derivative, Fungi)

Example 1
Example 2
RATIONAL SELECTION OF RIBOSOME ENGINEERING

(Cyclic Polypeptide, G(-) Bacteria)

Example 2

Hit rate:
Antibiotic resistance selection (ribosome engineering): 43% (3/7)
Random selection: 5.8% (4/69)

Example 3
YIELD IMPROVEMENT OF A FUNGAL ENZYME
Example 3
Example 4
STRAIN IMPROVEMENT BY COMBINING GENETIC ENGINEERING AND CLASSICAL MUTATION
Example 4

Combing heterologous gene expression with molecular and classical yield improvement, we optimized lactoferrin production.
For our client Agennix, Inc. (Houston, TX, USA) (Bio/Technology, 1995,13:498-503)

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