Exosomes, a type of extracellular vesicle (EV), are nano-sized vesicles enclosed by a lipid bilayer, capable of encapsulating various bioactive molecules such as nucleic acids, proteins, carbohydrates, and lipids. They act as key mediators of intercellular communication, regulating a range of physiological and pathological processes—including immune modulation, tissue repair, anti-inflammatory responses, and cellular regeneration. Thanks to their natural biocompatibility and high stability, exosomes have garnered significant attention in recent years. They are now widely utilized in food, nutritional supplements, and skincare formulations, positioning them as a highly promising next-generation bioactive ingredient.

Lactosome™ is a bioactive ingredient developed in-house by Panlabs, derived from exosome-like extracellular vesicles (EVs) released by probiotic Lactobacillus spp. These nanoscale vesicles, with a diameter of approximately 30–300 nm, are rich in proteins, lipids, and diverse metabolites, providing multiple biological functions including cellular communication, immune modulation, and skin regeneration.

Experimental data demonstrate that Lactobacillus-derived EVs deliver the following key skin benefits:

• Brightening: Inhibits tyrosinase activity, reducing melanin production
• Anti-inflammatory: Suppresses inflammation-related factors in the skin
• Repairing: Strengthens the stratum corneum and promotes regeneration
• Anti-aging: Maintains skin integrity and delays aging signs

Compared to animal-derived exosomes, Lactosome™ offers multiple advantages:

• Safe Source: Free from animal components, minimizing allergy and ethical concerns
• High Yield and Process Stability: Scalable for commercial production
• Environmentally Friendly: Aligned with sustainability and green manufacturing principles

Polydeoxyribonucleotide are highly purified, low-molecular-weight DNA fragments derived from cellular sources, known for their excellent biocompatibility and potent tissue regeneration potential. Acting through multiple cellular pathways, PDRN promotes tissue repair and modulates inflammatory responses, making it a sought-after functional ingredient in aesthetic medicine and biomedical applications. Research has demonstrated that PDRN exerts the following key biological effects:

• Cell Signaling Activation: Stimulates A2A adenosine receptors to trigger repair pathways
• Inflammation Modulation: Suppresses the expression of inflammatory cytokines such as IL-10, TNF-α, IL-6, and IL-8
• Regenerative Factor Promotion: Increases VEGF and various growth factors, enhancing collagen and fibrin synthesis
• Tissue Repair & Regeneration: Accelerates cell migration, angiogenesis, and tissue repair processes