Strain & Enzyme Improvement

Core Technology
Panlabs is dedicated to utilizing its expertise to offer customized services that help global enterprises enhance the value of microbial applications and optimize industrial production efficiency.


Strain Improvement

With over 50 years of experience in industrial microbial strain and enzyme improvement, Panlabs is highly skilled in operating various aerobic and anaerobic microorganisms. By employing professional, customized techniques combined with media optimization, we significantly increase the industrial production value of strains.In addition to large-scale shaker fermentation selection equipment, Panlabs has integrated micro-fermentation equipment and automated systems to accelerate strain screening, improve throughput and screening efficiency, and provide our customers with the highest quality strain solutions.


Enzyme Improvement and Products

Panlabs applies molecular biotechnology and protein engineering to develop highly efficient enzymes with enhanced catalytic performance. These enzymes operate under mild reaction conditions, reducing energy consumption and waste generationideal for green manufacturing and aligned with our customers' sustainability goals. Panlabs offers a diverse portfolio of enzymes for industrial and bioprocessing applications, including:

  • Enzymes: Amylase, Lipase, Nitrilase, Endonuclease, Glucose Oxidase
  • Proteases: SUMO protease, TEV protease

Global Microbial Strain Library

Panlabs is a leading microbial development company with a comprehensive strain library of over 20,000 fungal and actinomycete strains sourced from diverse geographical and ecological environments worldwide. We provide high-value natural products and microbial-based solutions with broad applications in pharmaceuticals, agriculture, functional foods, cosmetics, and environmental sustainability. Our strain library is not subject to the Nagoya Protocol, allowing unrestricted access for the discovery of novel bioactive natural compounds. If you are interested in exploring our microbial strain resources, please feel free to contact us!

Service Options Provided
Panlabs focuses on solving common technical challenges in the fermentation and manufacturing processes. Through innovative technologies and professional services, we enhance production efficiency and optimize processes, including:
Increase strain productivity and yield
Reduce by-product ratio
Enhance strain stability
Lower fermentation solution viscosity
Improve culture medium utilization and reduce costs
Shorten production time

Example 1
COMBINATION OF STRAIN IMPROVEMENT AND MEDIA DEVELOPMENT

(Terpenoid/Polyketide Derivative, Fungi)

Example 1
Example 2
RATIONAL SELECTION OF RIBOSOME ENGINEERING

(Cyclic Polypeptide, G(-) Bacteria)

Example 2

Hit rate:
Antibiotic resistance selection (ribosome engineering): 43% (3/7)
Random selection: 5.8% (4/69)

Example 3
YIELD IMPROVEMENT OF A FUNGAL ENZYME
Example 3
Example 4
STRAIN IMPROVEMENT BY COMBINING GENETIC ENGINEERING AND CLASSICAL MUTATION
Example 4

Combing heterologous gene expression with molecular and classical yield improvement, we optimized lactoferrin production.
For our client Agennix, Inc. (Houston, TX, USA) (Bio/Technology, 1995,13:498-503)

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